I am interested in uncovering novel mechanisms regulating white blood cell formation. Using an unbiased approach our laboratory has identified a number of proteins required for myelopoiesis. We are interested in determining the target molecular networks of these proteins to identify previously unknown pathways controlling the development of white blood cells in health and disease. This provides potential for the design of innovative therapeutics.
Experimental approaches to studying the nature and impact of splicing variation in zebrafish
The Zebrafish: Genetics, Genomics, and Transcriptomics, 4th Edition, Elsevier 2016.
Delineating the roles of neutrophils and macrophages in zebrafish regeneration models.
Int J Biochem Cell Biol. 2014 Nov;56C:92-106
Minor class splicing shapes the zebrafish transcriptome during development.
Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3062-7.
In vivo mutation of pre-mRNA processing factor 8 (Prpf8) affects transcript splicing, cell survival and myeloid differentiation.
FEBS Lett. 2013 Jul 11;587(14):2150-7. doi: 10.1016/j.febslet.2013.05.030. Epub 2013 May 25.
Immune priming: Mothering males modulate immunity.
Curr Biol. 2013 Jan 21;23(2):R76-8. doi: 10.1016/j.cub.2012.11.050.
Neutrophil-Delivered Myeloperoxidase Dampens the Hydrogen Peroxide Burst after Tissue Wounding in Zebrafish.
Curr Biol. 2012; 22(19):1818-1824
Mediator subunit 12 is required for neutrophil development in zebrafish.
PLoS One 2011 6(8): e23845