Professor Graham Lieschke is a clinical and research haematologist. He is internationally recognised for his research into blood disorders and cancer using zebrafish and mice. He is also a clinical haematologist at the Royal Melbourne Hospital, where he treats people with leukaemia and lymphoma.
Prof Lieschke received his medical science and medical degrees from the University of Melbourne in 1983. He undertook his specialist clinical training in medical oncology at the Royal Melbourne Hospital (RMH), obtaining his FRACP in 1991.
His undergraduate laboratory and clinical research cultivated his interest in haematology, and as the first Ludwig Institute/RMH Clinical Fellow, he was part of the team that introduced the white blood cell growth factors into clinical practice. In his PhD project at the Ludwig Institute for Cancer Research (Melbourne Branch), he undertook one of Australia’s first gene knockout projects, proving that G-CSF was a key physiological regulator of granulocyte production.
His postdoctoral training was at the Whitehead Institute in Cambridge, Massachusetts, USA, in tumour immunology. He returned to Australia in 1997 as an independent investigator. He established his zebrafish-based research program while at the Ludwig Institute for Cancer Research, and continued this as a Laboratory Head in the Cancer and Haematology Division of the Walter and Eliza Hall Institute.
His work seeks to exploit the unique strengths of the zebrafish model in genetics, embryology, and for visualizing cell behaviour in vivo to understand blood cell development and diseases.
His awards include: the John Maynard Hedstrom Research Fellowship of the Cancer Council of Victoria, a Howard Hughes Postdoctoral Research Fellowship for Physicians, a Wellcome Trust Senior Research Fellowship, and an NHMRC Senior Research Fellowship. The Ludwig Institute awarded him its inaugural George Hodgson Medal for Medical Science.
He has published over 100 scientific papers and co-edited 2 books. Prof. Lieschke is also passionate about the organ and choral music of J.S. Bach, an interest for which he was awarded the 2004 Dame Roma Mitchell Churchill Fellowship.
Keightley MC, Markmiller S, Love GC, Rasko JEJ, *Lieschke GJ, *Heath JK (*equal contributors). Experimental approaches to studying the nature and impact of splicing variation in zebrafish. Methods in Cell Biology (in press, accepted 10/Feb/16)
Keightley MC, Wang C-H, Pazhakh V, Lieschke GJ. Delineating the roles of neutrophils and macrophages in zebrafish regeneration models. International Journal of Biochemistry and Cell Biology. 56C:92-106. doi: 10.1016/j.biocel.2014.07.010. Epub 2014 Jul 21, 2014.
Lieschke GJ, Currie PD. Animal models of human disease – zebrafish swim into view. Nature Reviews – Genetics 8(5):353-67, 2007.
Carradice D, Lieschke GJ. Zebrafish hematology – sushi or science? Blood 111(7):3331-42, 2008.
Lieschke GJ, Trede NS. Fish immunology. Current Biology 19(16):R678-82, 2009.
Ellett F, Lieschke GJ. The use of zebrafish models in hematology research. Current Opinions in Pharmacology 10(5):563-70, 2010.
Pase L, Lieschke GJ. Discerning different in vivo roles of microRNAs by experimental approaches in zebrafish. Methods in Cell Biology. 104:353-378, 2011.
Wittmann C, Chockley P, Singh S, Pase L, Lieschke GJ, Grabher C. Hydrogen peroxide in inflammation – messenger, guide assassin. Advances in Hematology. 2012;2012:541471. Epub 2012 Jun 12.
A list of Prof Lieschke's publications appears on the NCBI website.
Lieschke GJ, Oates AC, Kawakami K (eds). Zebrafish: Methods and Protocols. Humana Press, Totowa NJ USA, 2009.
- Australian Medical Association (AMA)
- Medical Oncology Group of Australia (MOGA)
- Clinical Oncology Society of Australia (COSA)
- Haematology Society of Australia and New Zealand (HSANZ)
- Australia and New Zealand Society of Cell and Developmental Biology (ANZSCDB)
- National Association of Research Fellows (NARF)
- Melbourne Health Expert Scientific Review Panel
- American Society of Hematology (ASH)
- International Society of Experimental Hematology (ISEH)
- Society for Developmental Biology (SDB)
- Scientific Committee on Myeloid Biology (ASH)
- College of Experts (NRCNZ)
- Zebrafish Disease Models Society (ZDMS) Founding International Expert Board member