Professor Nilsson is currently involved in multiple research projects, all aimed to conduct extensive cellular, molecular and functional analyses of blood stem cells, their progeny and their bone marrow microenvironment.
Differentiation of Human Embryonic Stem Cells to HOXA+ Hemogenic Vasculature That Resembles the Aorta-Gonad-Mesonephros.
MOZ (KAT6A) is essential for the maintenance of classically defined adult hematopoietic stem cells.
Blood. 2016 Sep 23. pii: blood-2015-10-676072. [Epub ahead of print]
Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease.
JCI Insight. 2016 Sep 22;1(15):e86850.
I-bodies: human single domain antibodies that selectively antagonize chemokine receptor CXCR4.
J Biol Chem. 2016 Jun 10;291(24):12641-57. doi: 10.1074/jbc.M116.721050. Epub 2016 Apr 1.
Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist.
Nat Commun. 2016 Mar 15;7:11007. doi: 10.1038/ncomms11007.
Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere.
Angew Chem Int Ed Engl. 2016 Mar 7;55(11):3580-5. doi: 10.1002/anie.201510675. Epub 2016 Feb 5.
The role of CD44 in hemopoietic stem cell regulation during ontogeny.
Haematologica 2015 Jan 101: 26-37; Doi:10.3324/haematol.2015.135921
Megakaryocytes release factors required to thrombin cleave osteopontin, allowing for the negative regulation of hemopoietic stem cells.
Stem Cells. 2015 Jul;33(7):2351-7. doi: 10.1002/stem.2038. Epub 2015 May 15.
Design, synthesis and binding properties of a fluorescent alpha(9)beta(1)/alpha(4)beta(1) integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells.
Org Biomol. Chem 2014;12(6):965-978.
FOXN1GFP/w Reporter hESCs Enable Identification of Integrin-β4, HLA-DR and EpCAM as Markers of Human Pluripotent Stem Cell-Derived FOXN1+ Thymic Epithelial Progenitor Cells.
Stem Cell Reports. 2014 May 22;2(6):925-37. doi: 10.1016/j.stemcr.2014.04.009. eCollection 2014.
Dual α4β1/α9β1 integrin antagonists preferentially bind and mobilize hemopoietic stem cells from endosteal bone marrow.
Org Biomol Chem. 2014;12:965-978.
The role of Tenascin C in anchoring lymphoid progenitor cells within their niche.
Exp Hematol. 2013 Dec;41(12):1050-61. doi: 10.1016/j.exphem.2013.09.009. Epub 2013 Sep 29.
Understanding the role of the microenvironment during definitive hemopoietic development.
Exp Hematol. 2013 Sep;41(9):761-8. doi: 10.1016/j.exphem.2013.06.005. Epub 2013 Jun 22.
Megakaryocytes are a key niche component, regulating hemopoietic stem cell proliferation through cytokine release.
Stem Cell Res. 2013 Sep;11(2):782-92. doi: 10.1016/j.scr.2013.05.007. Epub 2013 May 28.
Phenotypically identical Hemopoietic Stem Cells isolated from different regions of bone marrow have different biological potential.
Blood. 2010 Oct 28;116(17):3185-96. doi: 10.1182/blood-2009-12-260703. Epub 2010 Jul 14.
Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with alpha9beta1 and alpha4beta1 integrins.
Blood. 2009 Jul 2;114(1):49-59. doi: 10.1182/blood-2009-01-197988. Epub 2009 May 5.
Osteopontin, a Key Component of the Hematopoietic Stem Cell Niche and Negative Regulator of Primitive Hematopoietic Progenitor Cells.
Blood. 2005 Aug 15;106(4):1232-9. Epub 2005 Apr 21.
Hyaluronan is synthesised by primitive hemopoietic cells, participates in their lodgement at the endosteum following transplantation and is involved in the regulation of their proliferation and differentiation in vitro.
Blood. 2003 Feb 1;101(3):856-62. Epub 2002 Sep 12.
Osteoblast-specific gene expression after transplantation of marrow cells: Implications for skeletal gene therapy.
Proc. Natl. Acad. Sci. USA. 1999;96(13):7294-7299.
Cells capable of bone production engraft from whole bone marrow transplants in nonablated mice.
J Exp Med. 1999 Feb 15;189(4):729–734.
Delayed hematopoietic development in the osteopetrotic (op/op) mouse.
J Exp Med. 1993 Jan 1;177(1):237-42.