Mirana Ramialison

ASSOCIATE PROFESSOR

  • mirana.ramialison@monash.edu
  • +61 (3) 9902 9645

Biography

A/Prof Ramialison received her Engineering degree from the University of Luminy, France, after which she worked as a programmer at the ERATO differentiation project in Kyoto. After obtaining her PhD in Developmental Genomics from the European Molecular Biology Laboratory in Heidelberg, Germany, she joined the Victor Chang Cardiac Research Institute in Sydney as an EMBO and HFSP Post-Doctoral Fellow. With an NHMRC/Heart Foundation Career Development Fellow, she relocated to Melbourne where she led the Systems Developmental Biology Laboratory at the Australian Regenerative Medicine Institute. She is now heading the Transcriptomics and Bioinformatics Laboratory at the Murdoch Children’s Research Institute. Her multi-disciplinary team focuses on designing tailored bioinformatics pipelines combined with a deep understanding of developmental processes to elucidate the gene regulatory networks underlying embryogenesis and congenital disease.

A/Prof Mirana Ramialison is available for supervision of Masters and PhD students in Bioinformatics, Computational Biology and Data Science.

Follow news from the Ramialison Group on twitterhttps://twitter.com/ramialison_lab

Click here for full list of publications on ORCID

Research interests

Despite the availability of genome sequences for many model organisms, our understanding of developmental gene regulatory networks (GRNs) is still relatively poor. My laboratory will focus on increasing our knowledge of network understanding by:

  1. generating quality datasets to unravel the nodes (genes, signalling pathways, regulatory elements) and edges (regulatory interactions) that compose the GRN,
  2. integrating this information using computational modelling, to recapitulate the complex processes that occur during development, and to predict the effects of perturbation as seen in congenital diseases,
  3. performing cross-species comparisons, to study the evolution of GRNs and investigate conserved and non-conserved regulatory properties and how they contribute to animal diversity.

Using a combination of bioinformatics tools and zebrafish as a model system, I intend to bring about significant advances in our appreciation of how GRNs drive embryonic development through the integration of cis-regulatory codes, how they are co-opted and modified during evolution and how they relate to disease pathophysiology.

Featured Publications

Authors Title Published In

del Monte-Nieto G, Ramialison M, Cherian A, Wu B, Aharonov A, D’Uva G, Bourke LM, Pitulescu ME, Chen H, Shou W, Adams RH, Harten SK, Tzahor E, Zhou B, Stainier D and Harvey RP.

Extracellular matrix dynamics reveals the building plan for cardiac trabeculation.

Nature. 2018 May;557(7705):439-445.

Nguyen PD, Hollway GE, Sonntag C, Miles LB, Hall TE, Berger S, Fernandez KJ, Gurevich DB, Cole NJ, Alaei S, Ramialison M, Sutherland RL, Polo JM, Lieschke GJ, Currie PD.

Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1. 

Nature. 2014 Aug 21; 512(7514):314-8.

Haudry Y* & Ramialison M*, Paten B, Wittbrodt J, Ettwiller L.

Using Trawler_standalone to discover overrepresented motifs in DNA and RNA sequences derived from various experiments including chromatin immunoprecipitation.

Nature Protocols. 2010; 5(2):323-34.

de Sena-Tomás C, Aleman AG, Ford C, Varshney A, Yao D, Harrington JK, Saúde L, Ramialison M, Targoff KL.

Activation of Nkx2.5 transcriptional program is required for adult myocardial repair.

Nature Communications. 2022 May 27;13(1):2970.

Deutsch EW, Ball CA, Berman JJ, Bova GS, Brazma A, Bumgarner RE, Campbell D, Causton HC, Christiansen JH, Daian F, Dauga D, Davidson DR, Gimenez G, Goo YA, Grimmond S, Henrich T, Herrmann BG, Johnson MH, Korb M, Mills JC, Oudes AJ, Parkinson HE, Pascal LE, Pollet N, Quackenbush J, Ramialison M, Ringwald M, Salgado D, Sansone SA, Sherlock G, Stoeckert CJ Jr, Swedlow J, Taylor RC, Walashek L, Warford A, Wilkinson DG, Zhou Y, Zon LI, Liu AY, True LD.

Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE).

Nature Biotechnology. 2008 Mar;26(3):305-12.

Nim HT, Dang L, Thiyagarajah H, Bakopoulos D, See M, Charitakis N, Sibbritt T, Eichenlaub MP, Archer SK, Fossat N, Burke RE, Tam PPL, Warr CG, Johnson TK#, Ramialison M#.

A cis-regulatory-directed pipeline for the identification of genes involved in cardiac development and disease.

Genome Biol. 2021 Dec 15;22(1):335.

Mohenska M*, Tan NM*, Tokolyi A*, Furtado MB, Costa MW, Perry AJ, Hatwell-Humble J, van Duijvenboden K, Nim HT, Ji YMM, Charitakis N, Bienroth D, Bolk F, Vivien C, Knaupp AS, Powell DR, Elliott DA, Porrello ER, Nilsson SK, Del Monte-Nieto G, Rosenthal NA, Rossello FJ, Polo JM#, Ramialison M#.

3D-cardiomics: A spatial transcriptional atlas of the mammalian heart.

J Mol Cell Cardiol. 2022 Feb;163:20-32.