
Nadinath Nillegoda
GROUP LEADER
- nadinath.nillegoda@monash.edu
Research interests
For more information, visit my PubMed and Google Scholar.
Featured Publications
Authors | Title | Published In |
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Mathangasinghe Y, Fauvet B, Jane SM, Goloubinoff P, Nillegoda NB. |
The Hsp70 chaperone system: distinct roles in erythrocyte formation and maintenance. |
Haematologica. 2021 (In press) |
Wentink AS, Nillegoda NB, Feufel J, UbartaitÄ— G, Schneider CP, De Los Rios P, Hennig J, Barducci A, Bukau B. |
Molecular dissection of amyloid disaggregation by human HSP70.  |
Nature. 2020 Nov 11. doi: 10.1038/s41586-020-2904-6. Online ahead of print. |
Serlidaki D, van Waarde MAWH, Rohland L, Wentink AS, Dekker SL, Kamphuis MJ, Boertien JM, Brunsting JF, Nillegoda NB, Bukau B, Mayer MP, Kampinga HH, Bergink S |
Functional diversity between HSP70 paralogs caused by variable interactions with specific co-chaperones. |
J Biol Chem. 2020 May 22;295(21):7301-7316. doi: 10.1074/jbc.RA119.012449. Epub 2020 Apr 13. PMID: 32284329 |
Alberts N, Mathangasinghe Y, Nillegoda NB. |
In Situ Monitoring of Transiently Formed Molecular Chaperone Assemblies in Bacteria, Yeast, and Human Cells. |
J Vis Exp. 2019 Sep 2;(151). doi: 10.3791/60172. |
Rosenzweig R*, Nillegoda NB*, Mayer MP* and Bukau B*.  (* Equal contribution) |
The Hsp70 chaperone network. |
Nat Rev Mol Cell Biol. 2019 in press. |
Nillegoda NB, Wentink AS, Bukau B. |
Protein disaggregation in multicellular organisms. |
Trends Biochem Sci. 2018 Apr;43(4):285-300. doi: 10.1016/j.tibs.2018.02.003. Epub 2018 Feb 28. |
Kirstein J, Arnsburg K, Scior A, Szlachcic A, Guilbride DL, Morimoto RI, Bukau B, Nillegoda NB. |
In vivo properties of the disaggregase function of J-proteins and Hsc70 in Caenorhabditis elegans stress and aging. |
Aging Cell. 2017 Dec;16(6):1414-1424. doi: 10.1111/acel.12686. Epub 2017 Oct 10. |
Garcia VM, Nillegoda NB, Bukau B, Morano KA. |
Substrate binding by the yeast Hsp110 nucleotide exchange factor and molecular chaperone Sse1 is not obligate for its biological activities. |
Mol Biol Cell. 2017 Jul 15;28(15):2066-2075. doi: 10.1091/mbc.E17-01-0070. Epub 2017 May 24. |
Nillegoda NB, Stank A, Malinverni D, Alberts N, Szlachcic A, Barducci A, De Los Rios P, Wade RC, Bukau B. |
Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes. |
Elife. 2017 May 15;6. pii: e24560. doi: 10.7554/eLife.24560. |
Żwirowski S, Kłosowska A, Obuchowski I, Nillegoda NB, Piróg A, Ziętkiewicz S, Bukau B, Mogk A, Liberek K. |
Hsp70 displaces small heat shock proteins from aggregates to initiate protein refolding. |
EMBO J. 2017 Mar 15;36(6):783-796. doi: 10.15252/embj.201593378. Epub 2017 Feb 20. |
Nillegoda NB, Kirstein J, Szlachcic A, Berynskyy M, Stank A, Stengel F, Arnsburg K, Gao X, Scior A, Aebersold R, Guilbride DL, Wade RC, Morimoto RI, Mayer MP, Bukau B. |
Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation. |
Nature. 2015 Aug 13;524(7564):247-51. doi: 10.1038/nature14884. Epub 2015 Aug 5. |
Gao X, Carroni M, Nussbaum-Krammer C, Mogk A, Nillegoda NB, Szlachcic A, Guilbride DL, Saibil HR, Mayer MP, Bukau B. |
Human Hsp70 disaggregase reverses Parkinson’s-linked α-Synuclein amyloid fibrils. |
Mol Cell. 2015 Sep 3;59(5):781-93. doi: 10.1016/j.molcel.2015.07.012. Epub 2015 Aug 20. |
Nillegoda NB, Bukau B. |
Metazoan Hsp70-based protein disaggregases: emergence and mechanisms. |
Front Mol Biosci. 2015 Oct 9;2:57. doi: 10.3389/fmolb.2015.00057. eCollection 2015. |
Hsieh TY, Nillegoda NB, Tyedmers J, Bukau B, Mogk A, Kramer G. |
Monitoring protein misfolding by site-specific labeling of proteins in vivo. |
PLoS One. 2014 Jun 10;9(6):e99395. doi: 10.1371/journal.pone.0099395. eCollection 2014. |
A network of ubiquitin ligases is important for the dynamics of misfolded protein aggregates in yeast. |
J Biol Chem. 2012 Jul 6;287(28):23911-22. doi: 10.1074/jbc.M112.341164. Epub 2012 May 16. |
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Rampelt H, Kirstein-Miles J, Nillegoda NB, Chi K, Scholz SR, Morimoto R, Bukaua B. |
Metazoan Hsp70 machines use Hsp110 to power protein disaggregation. |
EMBO J. 2012;31(21):4221-4235. doi:10.1038/emboj.2012.264. |
Mandal AK, Theodoraki MA, Nillegoda NB, Caplan AJ. |
Role of molecular chaperones in biogenesis of the protein kinome. |
Methods Mol Biol. 2011;787:75-81. doi: 10.1007/978-1-61779-295-3_6. |
Nillegoda NB, Theodoraki MA, Mandal AK, Mayo KJ, Ren HY, Sultana R, Wu K, Johnson J, Cyr DM, Caplan AJ. |
Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins. |
Mol Biol Cell. 2010 Jul 1;21(13):2102-16. doi: 10.1091/mbc.E10-02-0098. Epub 2010 May 12. |
Mandal AK, Gibney PA, Nillegoda NB, Theodoraki MA, Caplan AJ, Morano KA. |
Hsp110 chaperones control client fate determination in the hsp70-Hsp90 chaperone system. |
Mol Biol Cell. 2010 May 1;21(9):1439-48. doi: 10.1091/mbc.E09-09-0779. Epub 2010 Mar 17. |
Mandal AK, Nillegoda NB, Chen JA, Caplan AJ. |
Ydj1 protects nascent protein kinases from degradation and controls the rate of their maturation. |
Mol Cell Biol. 2008 Jul;28(13):4434-44. doi: 10.1128/MCB.00543-08. Epub 2008 Apr 28. |
Jones J, Wu K, Yang Y, Guerrero C, Nillegoda NB, Pan ZQ, Huang L. |
A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins. |
J Proteome Res. 2008 Mar;7(3):1274-87. doi: 10.1021/pr700749v. Epub 2008 Feb 5. |
Mandal AK, Lee P, Chen JA, Nillegoda NB, Heller A, DiStasio S, Oen H, Victor J, Nair DM, Brodsky JL, Caplan AJ. |
Cdc37 has distinct roles in protein kinase quality control that protect nascent chains from degradation and promote posttranslational maturation. |
J Cell Biol. 2007 Jan 29;176(3):319-28. Epub 2007 Jan 22. |