Current open positions:

  • EMBL Australia Group Leader in neural regeneration and/or organ engineering and synthetic biology
  • Postdoctoral Fellow with the Roselló-Díez Group
  • Postdoctoral Fellow with the Nillegoda Group (two positions)

EMBL Australia Group Leader in neural regeneration and/or organ engineering and synthetic biology

The Opportunity

Applications are invited from exceptionally motivated scientists with an ambitious and original vision for research that aligns with Australian Regenerative Medicine Institutes (ARMI) core research themes. ARMI is excited to be offering the opportunity for a Level C Senior Research Fellow or Level D Associate Professor (Research) to join its dynamic research leadership. ARMI welcomes applications from individuals who seek to make major transformational discoveries running their independent research program and who wish to accelerate their scientific research career as an EMBL Australia Group Leader.

ARMI is now in its 12th year and has established itself as a leader both in Australia and globally in the science of regenerative medicine. The 17 independent research groups now located within the Institute are divided into 5 themes, Heart and Muscle Development and Regeneration, Neural Regeneration, Immunity and Regeneration, Organ Engineering and Synthetic Biology and Stem Cells and Regeneration. All Institute researchers are co-located in purpose-built research facilities.

We are now seeking to recruit an outstanding Research Group Leader who will head up an independent research team undertaking research within one of two existing research themes:

Neural regeneration: The Centre for Dementia and Brain Repair is a newly formed research Centre with ARMI, leveraging off and complementing ARMI’s current research excellence in diverse research activities in the neural regeneration theme. A new expert in this area would bring the Centre to its full potential. We are looking to recruit an individual who will bring novel approaches to the issue of brain repair and neural degeneration.

Organ engineering and synthetic biology: Our aim is to strengthen capacity in this new research strength at ARMI and we seek to recruit an individual using novel and cutting-edge research methodologies and directions to the theme. Individuals with research strengths in creating new biological material from stem cells in vitro, understanding pluripotency, organoid biology, as well as those who study enhancing the body’s endogenous repair systems through tissue engineering approaches would complement the Institute’s current researchers in this theme.

The successful applicant will also participate in the collegial, collaborative culture of ARMI as well as the EMBL Australia Partner Laboratory Network (PLN). They will actively support the development of the PLN by participating in the various programs aimed at increasing research excellence and internationalisation.

EMBL Australia and Monash University are committed to supporting a gender-diverse and inclusive work environment, ensuring equal employment opportunity to attract and retain the best in their field. Attractive conditions and benefits are offered to ensure a flexible and family-friendly working environment.

Remuneration

Market competitive remuneration package will be negotiated with the successful candidates, including highly attractive salary packaging options.

Contract Term: The appointment will be a five-year fixed-term appointment. At the expiry of the five-year term, the University has the discretion to offer further employment subject to the University’s operational requirements and approvals.

Commencement Date: Anticipated commencement is in 2022 or as otherwise agreed.

How to apply

To apply, please provide a cover letter, CV (in English), and a summary of present and future research interests (max. 5 pages) to maree.trovato@emblaustralia.org.

Application closing date: Applications will be accepted until Wednesday 29 September 2021, 11:55pm AEST

Interviews are planned for and will be conducted initially via a virtual platform. Government restrictions allowing, and under public health advice, subsequent interviews will be held in Melbourne, Australia. Monash University will support applicants invited to interview with travel arrangements.

Enquiries

All enquiries will be held in confidence.
Contact: Professor Peter Currie, Director, Australian Regenerative Medicine Institute

E: Peter.Currie@monash.edu

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Postdoctoral Fellow with the Roselló-Díez Group

Job No.: 627232
Location: Clayton campus
Employment Type: Full-time
Duration: 12-month fixed-term appointment
Remuneration: $101,130 – $120,093 pa Level B (plus 10% employer superannuation)

The Opportunity

The Roselló-Díez group, based at the Australian Regenerative Medicine Institute at Monash University, studies the signals that operate within the bones and between them and other tissues/organs during development and regeneration.

An exciting opportunity exists for a post-doctoral research fellow to join the group to conduct research in the study of the genetic and epigenetic determinants of limb size in vertebrates. The main goal is to generate chimeric mice in which the limbs derive from stem cells of other species.

Ideally, we are seeking someone with a doctoral qualification in the relevant discipline area or equivalent qualifications or research experience and someone with experience in manipulation and transfer of the early mouse embryos, stem cell and tissue culture and molecular biology.

This role is a full-time position; however, flexible working arrangements may be negotiated.

At Monash University, we are committed to being a Child Safe organisation. Some positions at the University will require the incumbent to hold a valid Working with Children Check.

Your application must address the selection criteria. Please refer to “How to apply for Monash Jobs“.

Enquiries

Dr Alberto Roselló-Díez, Group Leader, +61 3 9902 9605

Closing Date

Monday 20 December 2021, 11:55pm AEDT

 

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Postdoctoral Fellow with the Nillegoda Group

Job No.: 624291
Location: Clayton campus
Employment Type: Full-time
Duration: 12-month fixed-term appointment
Remuneration:  $72,205 – $97,995 pa Level A (plus 10% employer superannuation)

The Opportunity

The Group of Dr Nadinath B. Nillegoda at the Australian Regenerative Medicine Institute, Monash University is seeking a dedicated and passionate Research Fellow interested in studying protein quality control pathways that prevent the accumulation of aggregated proteins and help repair cells using interdisciplinary approaches.

The overarching research theme of the Nillegoda Group revolves around investigating novel proteostasis-based directions for future therapeutic interventions that effectively slow neurodegeneration and disease progression by reversing protein aggregation and/or the associated cytotoxicities using a combination of advanced cell biological and biochemical methods with animal models of neurodegeneration. We are one of the pioneering groups in investigating the mechanism and regulation of chaperone-based human protein disaggregases (aggregate solubilizing machines) that have the potential to reverse protein aggregation and modulate the onset and severity of protein conformational disorders.

Brief project background: Accumulation of potentially toxic amorphous and amyloid type aggregates is a shared characteristic of aging and a wide range of neurodegenerative diseases.

This Research Fellow position will emphasize combining interdisciplinary approaches including cell biology and biochemistry to develop novel strategies that allow us to harness the human disaggregation activity to boost cellular defense against cytotoxicities associated with protein aggregation, which would open novel therapeutic avenues that can repair neurons and slow/reverse age associated neurodegenerative disorders. This research is supported by an NHMRC Investigator Grant.

We are seeking a highly motivated individual with a doctoral qualification or progress towards a doctoral qualification in cellular protein quality control systems, neurodegeneration, cell repair, molecular chaperones, and proteostasis.

This role is a full-time position; however, flexible working arrangements may be negotiated.

At Monash University, we are committed to being a Child Safe organisation. Some positions at the University will require the incumbent to hold a valid Working with Children Check.

Your application must address the selection criteria. Please refer to “How to apply for Monash Jobs“.

Enquiries

Dr Nadinath Nillegoda, Group Leader, +61 3 9905 3636

Closing Date

Monday 3 January 2021, 11:55pm AEDT

Please note: Monash University will be closed from 23 December 2021 until 3 January 2022 inclusive.

 

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Postdoctoral Fellow with the Nillegoda Group

Job No.: 627150
Location: Clayton campus
Employment Type: Full-time
Duration: 12-month fixed-term appointment
Remuneration:  $72,205 – $97,995 pa Level A (plus 10% employer superannuation)

The Opportunity

T

he Group of Dr Nadinath B. Nillegoda at the Australian Regenerative Medicine Institute, Monash University is seeking a dedicated and passionate Research Fellow interested in studying protein quality control pathways that prevent the accumulation of aggregated proteins and help repair cells using interdisciplinary approaches.

The Research Fellow (Proteostasis) will support the Group Leader on a research grant titled “Identification of disaggregase modulators: a new class of anti-neurodegenerative drugs”.

Neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease are often characterized by the formation and persistence of protein aggregates (amyloids) in neuronal tissue that initiate the disease process by a gain-of-toxicity mechanism. Despite global efforts to bolster dementia research, there are currently no effective treatments or cures. Our ground-breaking research uncovered the primary protein aggregate solubilizing machine (disaggregase) constituted by the Heat shock protein 70 (Hsp70) chaperone system in human cells. This discovery introduced a previously unacknowledged metazoan cellular repair activity fundamentally important for decreasing cellular aggregate levels and the associated cytotoxicities linked to neurodegeneration.

The proposed work revolves around dissecting the gene regulators and identifying small molecule regulators of protein disaggregases, a first in the field – The small molecule regulators will provide the basis to develop a new class of anti-neurodegenerative drugs.

We are seeking a highly motivated and talented individual with a doctoral qualification or progress towards a doctoral qualification in cellular protein quality control systems, neurodegeneration, cell repair, molecular chaperones and proteostasis. Exceptional candidates from other fields in cell biology, biochemistry and neuroscience will also be considered.

A strong track record of publications directly linked to proteostasis and/or characterization of proteins using cutting edge biochemical and biophysical techniques in peer-reviewed journals is a must. Required techniques/methods include extensive knowledge in proteostasis, neurodegeneration, cellular protein quality control pathways, protein folding and molecular chaperones, protein aggregation and cellular stress pathways and/or protein degradation.

This role is a full-time position; however, flexible working arrangements may be negotiated.

At Monash University, we are committed to being a Child Safe organisation. Some positions at the University will require the incumbent to hold a valid Working with Children Check.

Your application must address the selection criteria. For instructions on how to apply, please refer to “How to apply for Monash Jobs“.

Enquiries

Dr Nadinath Nillegoda, Group Leader, +61 3 9905 3636

Closing Date

Wednesday 5 January 2022, 11:55pm AEDT

Please note: Monash University will be closed from 23 December 2021 until 3 January 2022 inclusive.

 

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