The Lieschke group studies the haemopoietic system and leukocytes. The haemopoietic system is a collection of organs and tissues (bone marrow, spleen, lymph nodes etc.) responsible for the production of blood in the body.


Leukocytes (white blood cells) are the keys cells involved for counteracting foreign substances and disease. They also play a major role in determining whether tissue repairs and regenerates rather than scars after injury. 


Research


Using the zebrafish as a model organism, the Lieschke group study blood cell development and function. They also look at mutant zebrafish with faulty blood cell development to find insights into the genes that regulate the haemopoietic system.


Mutant zebrafish also assist with understanding the role of leukocytes in inflammation and healing. This information is used to create infection models that stimulate leukocytes in action, which helps the group investigate the host-pathogen response. 

Lieschke group photo

 

  • Discovery of genes critical for white blood cell development 
  • How the inflammatory response is regulated
  • How modulating the inflammatory white blood cells might tip the outcome to favour regeneration rather than scarring
  • Investigating how white blood cells keep out and contain micro-organisms. 

Featured Publications

More Publications

Authors
Title
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Nguyen PD, Hollway GE, Sonntag C, Miles LB, Hall TE, Berger S, Fernandez KJ, Gurevich DB, Cole NJ, Alaei S, Ramialison M, Sutherland RL, Polo JM, Lieschke GJ, Currie PD.

Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1.

Nature. 2014 Aug 21;512(7514):314-8. doi: 10.1038/nature13678. Epub 2014 Aug 13.

Markmiller S, Cloonan N, Lardelli RM, Doggett K, Keightley MC, Boglev Y, Trotter AJ, Ng AY, Wilkins SJ, Verkade H, Ober EA, Field HA, Grimmond SA, Lieschke GJ, Stainier DYR, Heath JK.

Minor class splicing shapes the zebrafish transcriptome during development.

Proceedings of the National Academy of Science (USA) Feb 25;111(8)3962-7. Doi: 10.1073/pnas.1305536111. Epub 2014 Feb 10, 2014.

Palha N, Guivel-Benhassine F, Briolat V, Lutfalla G, Sourisseau M, Ellett F, Wang C.-H, Lieschke GJ, Herbomel P, Schwartz O, Levraud J-P.

Real-time visualization of Chikungunya virus infection and host interferon response in zebrafish.

PLoS Pathog. 2013;9(9):e1003619. doi: 10.1371/journal.ppat.1003619. Epub 2013 Sep 5.

Henry KM, Pase L, Ramos-Lopez CF, Lieschke GJ, Renshaw SA, Reyes-Aldasoro CC.

PhagoSight: an open-source MATLAB package for the analysis of fluorescent neutrophil and macrophage migration.

PLoS One. 2013 Aug 30;8(8):e72636. doi: 10.1371/journal.pone.0072636. eCollection 2013.

Hall CJ, Boyle RH, Astin JW, Flores MV, Oehlers SH, Sanderson LE, Ellett F, Lieschke GJ, Crosier KE, Crosier PS.

Immunoresponsive gene 1 augments bactericidal activity of macrophage-lineage cells by regulating -oxidation-dependent mitochondrial ROS production.

Cell Metab. 2013 Aug 6;18(2):265-78. doi: 10.1016/j.cmet.2013.06.018.

Keightley MC, Crowhurst MO, Layton JE, Beilharz T, Markmiller S, Varma S, Hogan BM, de Jong-Curtain TA, Heath JK, Lieschke GJ.

In vivo mutation of pre-mRNA processing factor 8 (Prpf8) affects transcript splicing, cell survival and myeloid differentiation.

FEBS Lett. 2013 Jul 11;587(14):2150-7. doi: 10.1016/j.febslet.2013.05.030. Epub 2013 May 25.

Boglev Y, Badrock AP, Trotter AJ, Richardson EJ, Hall NE, de Jong Curtain TA, Ng AY, Verkade H, Ober EA, Field HA, Shin D, Shin CH, Hannan KM, Hannan RD, Pearson RB, Kim S-H, Ess KC, Lieschke GJ, Stainier DYR, Heath JK.

Autophagy induction is a Tor- and Tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis.

PLoS Genet. 2013;9(2):e1003279. doi: 10.1371/journal.pgen.1003279. Epub 2013 Feb 7.

Cai H, Santiago FS, Prado-Lourenco L, Wang B, Patrikakis M, Davenport MP, Maghzal GJ, Stocker R, Parish CR, Chong BH, Lieschke GJ, Wong T-W, Chesterman CN, Francis D, Moloney FJ, Barnetson RStC, Halliday GM, Khachigian LM.

DNAzyme Targeting c-Jun Suppresses Skin Cancer.

Sci Transl Med. 2012 Jun 20;4(139):139ra82. doi: 10.1126/scitranslmed.3003960.

Lieschke GJ, Oates AC, Kawakami K (eds).

Zebrafish: Methods and Protocols.

Humana Press, Totowa NJ USA, 2009.

Lieschke GJ, Trede NS.

Fish immunology.

Curr Biol. 2009 Aug 25;19(16):R678-82. doi: 10.1016/j.cub.2009.06.068.

Pase L, Layton JE, Kloosterman WP, Carradice D, Waterhouse PM, Lieschke GJ.

miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2.

Blood. 2009 Feb 19;113(8):1794-804. doi: 10.1182/blood-2008-05-155812. Epub 2008 Oct 10.

Carradice D, Lieschke GJ.

Zebrafish hematology – sushi or science?

Blood. 2008 Apr 1;111(7):3331-42. doi: 10.1182/blood-2007-10-052761. Epub 2008 Jan 8.

Lieschke GJ, Currie PD.

Animal models of human disease – zebrafish swim into view.

Nat Rev Genet. 2007 May;8(5):353-67.