Mikaël Martino


  • mikael.martino@monash.edu
  • +61 (3) 9902 9719

Featured Publications

Authors Title Published In

Tan JL, Lash B, Karami R, Nayer B, Lu YZ, Piotto C, Julier Z, Martino MM.

Restoration of the healing microenvironment in diabetic wounds with matrix-binding IL-1 receptor antagonist.

Communications Biolology. 2021 Mar 26;4(1):422. doi: 10.1038/s42003-021-01913-9.

Ratnayake D, Nguyen PD, Rossello FJ, Wimmer VC, Tan JL, Galvis LA, Julier Z, Wood AJ, Boudier T, Isiaku AI, Berger S, Oorschot V, Sonntag C, Rogers KL, Marcelle C, Lieschke GJ, Martino MM, Bakkers J, Currie PD.

Macrophages provide a transient muscle stem cell niche via NAMPT secretion.

Nature. 2021 Mar;591(7849):281-287. doi: 10.1038/s41586-021-03199-7.

Maruyama K, Kidoya H, Takemura N, Sugisawa E, Takeuchi O, Kondo T, Eid MMA, Tanaka H, Martino MM, Takakura N, Takayama Y, Akira S, Vandenbon A, Kumagai Y.

Zinc Finger Protein St18 Protects against Septic Death by Inhibiting VEGF-A from Macrophages.

Cell Reports. 2020 Jul 14;32(2):107906. doi: 10.1016/j.celrep.2020.107906.

Julier Z, Karami R, Nayer B, Lu YZ, Park AJ, Maruyama K, Kuhn GA, Müller R, Akira S, Martino MM.

Enhancing the regenerative effectiveness of growth factors by local inhibition of interleukin-1 receptor signaling.

Science Advances. 2020 Jun 12;6(24):eaba7602. doi: 10.1126/sciadv.aba7602. eCollection 2020 Jun.

Mochizuki M, Güç E, Park AJ, Julier Z, Briquez PS, Kuhn GA, Müller R, Swartz MA, Hubbell JA, Martino MM.

Growth factors with enhanced syndecan binding generate tonic signalling and promote tissue healing.

Nature Biomedical Engineering. 2020 Apr;4(4):463-475. doi: 10.1038/s41551-019-0469-1.

Ren X, Zhao M, Lash B, Martino MM, Julier Z.

Growth Factor Engineering Strategies for Regenerative Medicine Applications.

Frontiers in Bioengineering and Biotechnolology. 2020 Jan 21;7:469. doi: 10.3389/fbioe.2019.00469. eCollection 2019.

Banfi A, Holnthoner W, Martino MM, Ylä-Herttuala S.

Vascularization for regenerative medicine.

Front Bioeng Biotechnol. 2018; 6: 175. doi: 10.3389/fbioe.2018.00175. Epub 2018 Nov 21.

Hubbell JA, Martino MM, Briquez PSM.

Protein-binding peptide isolated from placenta growth factor.

US Patent 9,879,062 2018.

Maruyama K, Takayama Y, Sugisawa E, Yamanoi Y, Yokawa T, Kondo T, Ishibashi KI, Sahoo BR, Takemura N, Mori Y, Kanemaru H, Kumagai Y, Martino MM, Yoshioka Y, Nishijo H, Tanaka H, Sasaki A, Ohno N, Iwakura Y, Moriyama Y, Nomura M, Akira S, Tominaga M.

The ATP Transporter VNUT Mediates Induction of Dectin-1-Triggered Candida Nociception.

iScience. 2018 Aug 31;6:306-318. doi: 10.1016/j.isci.2018.08.007.

Piotto C, Julier Z, Martino MM.

Immune regulation of tissue repair and regeneration via miRNAs-new therapeutic target.

Front Bioeng Biotechnol. 2018 Jul 13;6:98. doi: 10.3389/fbioe.2018.00098. eCollection 2018.

Larouche J, Sheoran S, Maruyama K, Martino MM.

Immune regulation of skin wound healing: mechanisms and novel therapeutic targets.

Adv Wound Care (New Rochelle). 2018 Jul 1;7(7):209-231. doi: 10.1089/wound.2017.0761.

Li J, Tan J, Martino MM, Lui KO.

Regulatory T-Cells: Potential regulator of tissue repair and regeneration.

Front Immunol. 2018 Mar 23;9:585. doi: 10.3389/fimmu.2018.00585. eCollection 2018.

Pilehvar-Soltanahmadi Y, Nouri M, Martino MM, Fattahi A, Alizadeh E, Darabi M, Rahmati-Yamchi M, Zarghami N.

Cytoprotection, proliferation and epidermal differentiation of adipose tissue-derived stem cells on emu oil based electrospun nanofibrous mat.

Exp Cell Res. 2017 Aug 15;357(2):192-201. doi: 10.1016/j.yexcr.2017.05.015. Epub 2017 May 17.

Maruyama K, Takemura N, Martino MM, Kondo T, Akira S.

Netrins as prophylactic targets in skeletal diseases: A double-edged sword?

Pharmacol Res. 2017 Aug;122:46-52. doi: 10.1016/j.phrs.2017.05.011. Epub 2017 May 30.

Maruyama K, Takayama Y, Kondo T, Ishibashi KI, Sahoo BR, Kanemaru H, Kumagai Y, Martino MM, Tanaka H, Ohno N, Iwakura Y, Takemura N, Tominaga M, Akira S.

Nociceptors boost the resolution of fungal osteoinflammation via the TRP channel-CGRP-Jdp2 axis.

Cell Rep. 2017 Jun 27;19(13):2730-2742. doi: 10.1016/j.celrep.2017.06.002

Julier Z, Park AJ, Briquez PS, Martino MM.

Promoting tissue regeneration by modulating the immune system.

Acta Biomater. 2017 Apr 15;53:13-28. doi: 10.1016/j.actbio.2017.01.056. Epub 2017 Jan 22.

Maruyama K, Kawasaki T, Hamaguchi M, Hashimoto M, Furu M, Ito H, Fujii T, Takemura N, Karuppuchamy T, Kondo T, Kawasaki T, Fukasaka M, Misawa T, Saitoh T, Suzuki Y, Martino MM, Kumagai Y, Akira S.

Bone-protective functions of netrin 1 protein.

J Biol Chem. 2016 Nov 11;291(46):23854-23868. Epub 2016 Sep 28.

Martino MM, Maruyama K, Kuhn AG, Satoh T, Takeuchi O, Müller R, Shizuo A.

Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration.

Nat Commun. 2016;7:11051. Epub: 2016 Mar 22. doi: 10.1038/ncomms11051. PMCID: PMC4804175.

Briquez PS, Clegg LE, Martino MM, Gabhann FM, Hubbell JA.

Design principles for therapeutic angiogenic materials.

Nat Rev Mats 2016;1:15006. doi: 10.1038/natrevmats.2015.6.

Briquez PS, Hubbell JA, Martino MM.

Extracellular matrix-inspired growth factor delivery systems for skin wound healing.

Adv Wound Care (New Rochelle). 2015 Aug 1;4(8):479-489. doi:10.1089/wound.2014.0603.

Martino MM, Briquez PS, Maruyama K, Hubbell JA.

Extracellular matrix-inspired growth factor delivery systems for bone regeneration.

Adv Drug Deliv Rev; 2015 Nov 1;94:41-52. doi: 10.1016/j.addr.2015.04.007.

Najjar M, Manzoli V, Martino MM, Molano RD, Pileggi A, Camillo R, Hubbell JA, Tomei AA.

Fibrin gels engineered with pro-angiogenic growth factors promote engraftment of pancreatic islets in extrahepatic sites in mice.

Biotechnol Bioeng; 2015 Sep;112(9):1916-26. doi: 10.1002/bit.25589.

Martino MM, Brkic S, Bovo E, Burger M, Schaefer DJ, Briquez PS, Gianni-Barrera R, Hubbell JA, Banfi A.

Extracellular matrix and growth factor engineering for controlled angiogenesis in regenerative medicine. 

Front Bioeng Biotechnol; 2015 Apr 1;3:45. doi: 10.3389/fbioe.2015.00045.

Maruyama K, Fukasaka M, Uematsu S, Takeuchi O, Kondo T, Saitoh T, Martino MM, Akira S.

AZI2 regulates bone mass by fine-tuning osteoclast survival.

J Biol Chem; 2015 Apr 10;290(15):9377-86. doi: 10.1074/jbc.M114.631374.

Julier Z, Martino MM, de Titta A, Jeanbart J, Hubbell JA.

The immunological activity of the extra domain A of fibronectin (EDA) in agonizing TLR4 and inducing CD8+ T cell responses is cryptic and exposed by elastase 2.

Sci Rep; 2015 Feb 24;5:8569. doi: 10.1038/srep08569.

Vila OF, Martino MM, Nebuloni L, Kuhn G, Pérez-Amodio S, Müller R, Hubbell JA, Rubio N, Blanco J.

Bioluminescent and μCT tomography imaging of bone repair induced by fibrin-binding growth factors.

Acta Biomater; 2014 Oct;10(10):4377-89. doi: 10.1016/j.actbio.2014.05.028.

Sacchi V, Mittermayr M, Hartinger J, Martino MM, Wolbank S, Hofmann A, Largo R, Marshall J, Groppa E, Gianni-Barrera R, Ehrbar M, Hubbell JA, Redl H, Banfi A.

Sustained and highly tunable delivery of recombinant VEGF164 from optimized fibrin matrices ensures normal, stable and functional angiogenesis.

Proc Natl Acad Sci U S A; 2014 May 13;111(19):6952-7. doi: 10.1073/pnas.1404605111.

Martino MM, Briquez PS, Güç E, Tortelli F, Kilarski WW, Metzger S, Rice JJ, Kuhn GA, Müller R, Swartz MA, Hubbell JA.

Growth factors engineered for super-affinity to the extracellular matrix enhance tissue healing.

Science; 2014 Feb 21;343(6173):885-8. doi: 10.1126/science.1247663.

Mosiewicz KA, Kolb L, van der Vlies AJ, Martino MM, Lienemann P, Hubbell JA, Ehrbar M, Lutolf MP.

In situ cell fate manipulation by light-activated enzymatic hydrogel patterning.

Nat Mater; 2013 Nov;12(11):1072-8. doi: 10.1038/nmat3766.

Maruyama K, Uematsu S, Kondo T, Takeuchi O, Martino MM, Kawasaki T, Akira S.

Strawberry notch homologue 2 plays a key role in fine-tuning osteoclast fusion.

J Exp Med; 2013 Sep 23;210(10):1947-60. doi: 10.1084/jem.20130512.